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SOCS7 Antibody - N-terminal region : FITC (ARP53700_P050-FITC)

Product Specifications

Gene Name

Suppressor of cytokine signaling 7

Gene Aliases

NAP4, NCKAP4

Gene ID

30837

Swiss Prot

O14512

Accession Number

NP_055413

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS7

Target

SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Partner Proteins

SEPT6; SORBS3; STAT5A; STAT3; CUL5; IRS4; PIK3R2; TUBB4B; TUBA1A; IRS2; NCK1; PLCG1; PIK3R1; EGFR; GRB2

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

SOCS7 is supported by BioGPS gene expression data to be expressed in OVCAR3

Concentration

0.5 mg/ml

Homology

Cow: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

64kDa

References & Citations

Kremer, B.E., (2007) Cell 130 (5), 837-850

Shipping Conditions

Wet Ice

Product Datasheet

Anti-SOCS7 (ARP53700_P050-FITC) antibody

Protein Length

581

NCBI Gene Symbol

SOCS7

NCBI GB Accession Number

SOCS7

Host or Source

Rabbit

Protein Name

Suppressor of cytokine signaling 7

Nucleotide Accession Number

NM_014598

Peptide Sequence

LDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCP

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