Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

PDE12 Antibody - middle region : HRP (ARP53350_P050-HRP)

Selected Variant

ARP53350_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Phosphodiesterase 12

Gene Aliases

2-PDE, 2'-PDE

Gene ID

201626

Swiss Prot

Q6L8Q7

Accession Number

NP_808881

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human 2'-PDE

Target

2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) . Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Partner Proteins

SUMO2; SUMO1; UBC; NEDD8; DCTPP1; NPLOC4; UBQLN2; EHD1; WDR4; PDLIM5; SAE1; UBA2; CUL5; XPNPEP1; STAT6; RAD23B; PGGT1B; DNAJB1; ADSL; APEX2; COPS5; CUL3; UBL4A

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

PDE12 is supported by BioGPS gene expression data to be expressed in OVCAR3

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

67kDa

References & Citations

Kubota, K., (2004) J. Biol. Chem. 279 (36), 37832-37841

Shipping Conditions

Wet Ice

Protein Length

609

NCBI Gene Symbol

PDE12

NCBI GB Accession Number

PDE12

Host or Source

Rabbit

Protein Name

2',5'-phosphodiesterase 12

Nucleotide Accession Number

NM_177966

Peptide Sequence

CLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKW

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CD66 (CEA) (COL-1), CF647 conjugate, 0.1mg/mL
BNC470002-500 1x 500 µL

CD66 (CEA) (COL-1), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Cytokeratin 14 (KRT14/532), CF405S conjugate, 0.1mg/mL
BNC040532-500 1x 500 µL

Cytokeratin 14 (KRT14/532), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Progesterone Receptor (PR500), CF568 conjugate, 0.1mg/mL
BNC680500-100 1x 100 µL

Progesterone Receptor (PR500), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) (rCDX2/1690), CF568 conjugate, 0.1mg/mL
BNC683632-100 1x 100 µL

CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker) (rCDX2/1690), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
ETS1 (Marker of Tumor Metastasis) (ETS1/1801), CF647 conjugate, 0.1mg/mL
BNC471801-100 1x 100 µL

ETS1 (Marker of Tumor Metastasis) (ETS1/1801), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Anti-TIMM8A/DDP Antibody Picoband®
A07659-1 100 µg/Vial

Anti-TIMM8A/DDP Antibody Picoband®

Sign In for Pricing
View Details