PDE12 Antibody - middle region : FITC (ARP53350_P050-FITC)
Product Specifications
Gene Name
Phosphodiesterase 12
Gene Aliases
2-PDE, 2'-PDE
Gene ID
201626
Swiss Prot
Q6L8Q7
Accession Number
NP_808881
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human 2'-PDE
Target
2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) . Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Partner Proteins
SUMO2; SUMO1; UBC; NEDD8; DCTPP1; NPLOC4; UBQLN2; EHD1; WDR4; PDLIM5; SAE1; UBA2; CUL5; XPNPEP1; STAT6; RAD23B; PGGT1B; DNAJB1; ADSL; APEX2; COPS5; CUL3; UBL4A
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
PDE12 is supported by BioGPS gene expression data to be expressed in OVCAR3
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
67kDa
References & Citations
Kubota, K., (2004) J. Biol. Chem. 279 (36), 37832-37841
Shipping Conditions
Wet Ice
Protein Length
609
NCBI Gene Symbol
PDE12
NCBI GB Accession Number
PDE12
Host or Source
Rabbit
Protein Name
2',5'-phosphodiesterase 12
Nucleotide Accession Number
NM_177966
Peptide Sequence
CLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKW
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