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PDE12 Antibody - middle region : Biotin (ARP53350_P050-Biotin)

Selected Variant

ARP53350_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Phosphodiesterase 12

Gene Aliases

2-PDE, 2'-PDE

Gene ID

201626

Swiss Prot

Q6L8Q7

Accession Number

NP_808881

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human 2'-PDE

Target

2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) . Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Partner Proteins

SUMO2; SUMO1; UBC; NEDD8; DCTPP1; NPLOC4; UBQLN2; EHD1; WDR4; PDLIM5; SAE1; UBA2; CUL5; XPNPEP1; STAT6; RAD23B; PGGT1B; DNAJB1; ADSL; APEX2; COPS5; CUL3; UBL4A

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

PDE12 is supported by BioGPS gene expression data to be expressed in OVCAR3

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

67kDa

References & Citations

Kubota, K., (2004) J. Biol. Chem. 279 (36), 37832-37841

Shipping Conditions

Wet Ice

Protein Length

609

NCBI Gene Symbol

PDE12

NCBI GB Accession Number

PDE12

Host or Source

Rabbit

Protein Name

2',5'-phosphodiesterase 12

Nucleotide Accession Number

NM_177966

Peptide Sequence

CLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKW

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