KLB Antibody - middle region : HRP (ARP53325_P050-HRP)
Selected Variant
ARP53325_P050-HRP
Size: 100 µL
Product Specifications
Gene Name
Klotho beta
Gene Aliases
BKL
Gene ID
152831
Swiss Prot
Q86Z14
Accession Number
NP_783864
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human KLB
Target
KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
Partner Proteins
FGF21
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 93%; Guinea Pig: 85%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
120kDa
References & Citations
Lu, L., (2008) Cancer Invest. 26 (2), 185-192
Shipping Conditions
Wet Ice
Protein Length
1044
NCBI Gene Symbol
KLB
NCBI GB Accession Number
KLB
Host or Source
Rabbit
Protein Name
Beta-klotho
Nucleotide Accession Number
NM_175737
Peptide Sequence
DAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQG
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