TMPRSS6 Antibody - N-terminal region : Biotin (ARP53188_P050-Biotin)
Product Specifications
Gene Name
Transmembrane protease, serine 6
Gene Aliases
MT2, IRIDA
Gene ID
164656
Swiss Prot
Q8IU80
Accession Number
NP_705837
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human TMPRSS6
Target
TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Partner Proteins
LAMA1; FN1; COL1A1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
90kDa
References & Citations
Finberg, K.E., (2008) Nat. Genet. 40 (5), 569-571
Shipping Conditions
Wet Ice
Protein Length
811
NCBI Gene Symbol
TMPRSS6
NCBI GB Accession Number
TMPRSS6
Host or Source
Rabbit
Protein Name
Transmembrane protease serine 6
Nucleotide Accession Number
NM_153609
Peptide Sequence
LLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
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