CAMKK2 Antibody - N-terminal region: Biotin (ARP53184_P050-Biotin)

CAMKK2 is a calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 seems to be involved in hippocampal activation of CREB1.The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.

HSP90AA1; APP; UBC; NEDD4; CEP63; ESYT2; FANCI; OBSL1; ATG4B; XPOT; GCN1L1; IQGAP2; SMC3; SLC25A11; SMC1A; PRKDC; PRKAG1; PRKAA2; IRAK1; FLNC; FLNA; MAPK14; CALM1; CAMK4; CAMK1; PRKACA; SGK1

There is BioGPS gene expression data showing that CAMKK2 is expressed in 721_B, Hela, HepG2 CAMKK2 is supported by BioGPS gene expression data to be expressed in Jurkat, MCF7

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.