MAP3K7IP1 Antibody - N-terminal region : Biotin (ARP53182_P050-Biotin)

The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

MAGED1; BAG2; MAP3K7; TIRAP; MDM2; SLMAP; NPM1; BIRC3; TRIP6; PPP2R1A; PPP2CB; GRB2; FN1; CDK5RAP3; TAB2; CORO1A; WTAP; MAPK8IP1; UBC; MAPK14; BST2; MAPK12; HSP90AA1; NOTCH1; IKBKB; GRK5; EGFR; STE11; BIRC7; NAIP; XIAP; OGT; TAB3; NR2C2; ARRB2; ARAP1; ACA

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.