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RDH12 Antibody - middle region : HRP (ARP52973_P050-HRP)

Product Specifications

Gene Name

Retinol dehydrogenase 12 (all-trans/9-cis/11-cis)

Gene Aliases

RP53, LCA13, SDR7C2

Gene ID

145226

Swiss Prot

Q96NR8

Accession Number

NP_689656

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human RDH12

Target

RDH12 is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. RDH12 also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3) . The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3) .

Partner Proteins

RBPMS; UBC; ANXA8L1; MAP1LC3A; BUB1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 92%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Pig: 86%; Rabbit: 85%; Rat: 79%; Yeast: 79%; Zebrafish: 92%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

35kDa

References & Citations

Sun, W., (2007) Vision Res. 47 (15), 2055-2066

Shipping Conditions

Wet Ice

Protein Length

316

NCBI Gene Symbol

RDH12

NCBI GB Accession Number

RDH12

Host or Source

Rabbit

Protein Name

Retinol dehydrogenase 12

Nucleotide Accession Number

NM_152443

Peptide Sequence

AKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTAREGAQT

Frequently Asked Questions

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