RDH12 Antibody - middle region : Biotin (ARP52972_P050-Biotin)
Product Specifications
Gene Name
Retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Gene Aliases
RP53, LCA13, SDR7C2
Gene ID
145226
Swiss Prot
Q96NR8
Accession Number
NP_689656
Host
Rabbit
Reactivity
Human, Rat, Dog, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human RDH12
Target
RDH12 is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. RDH12 also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3) .The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3) .
Partner Proteins
RBPMS; UBC; ANXA8L1; MAP1LC3A; BUB1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Dog: 93%; Human: 100%; Pig: 79%; Rat: 79%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
35kDa
References & Citations
Sun, W., (2007) Vision Res. 47 (15), 2055-2066
Shipping Conditions
Wet Ice
Protein Length
316
NCBI Gene Symbol
RDH12
NCBI GB Accession Number
RDH12
Host or Source
Rabbit
Protein Name
Retinol dehydrogenase 12
Nucleotide Accession Number
NM_152443
Peptide Sequence
HIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAV
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