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NEURL2 Antibody - N-terminal region : HRP (ARP52524_P050-HRP)

Selected Variant

ARP52524_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Neuralized homolog 2 (Drosophila)

Gene Aliases

OZZ, OZZ-E3, C20orf163

Gene ID

140825

Swiss Prot

Q9BR09

Accession Number

NP_542787

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human NEURL2

Target

NEURL2 contains 1 NHR (neuralized homology repeat) domain and 1 SOCS box domain. NEURL2 plays an important role in the process of myofiber differentiation and maturation. NEURL2 is the probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. NEURL2 probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, it controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.

Partner Proteins

CTNNB1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

32kDa

References & Citations

Song, R., (2006) J. Biol. Chem. 281 (47), 36391-36400

Shipping Conditions

Wet Ice

Protein Length

285

NCBI Gene Symbol

NEURL2

NCBI GB Accession Number

NEURL2

Host or Source

Rabbit

Protein Name

Neuralized-like protein 2

Nucleotide Accession Number

NM_080749

Peptide Sequence

MAAASEPVDSGALWGLERPEPPPTRFHRVHGANIRVDPSGTRATRVESFA

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