EGLN3 Antibody - C-terminal region : Biotin (ARP52402_P050-Biotin)

Product Specifications

Gene Name

Egl nine homolog 3 (C. elegans)

Gene Aliases

PHD3, HIFPH3, HIFP4H3

Gene ID

112399

Swiss Prot

Q9H6Z9

Accession Number

NP_071356

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human EGLN3

Target

EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.

Partner Proteins

FOXJ2; SERTAD1; NCAPH2; EFHC2; ABI2; SIAH2; REL; HIF1A; TTC23L; SQSTM1; HEXIM1; IKBKG; IKBKB; CHUK; MAPK7; MAPK6; MAPK1; PKM; EPAS1; UBD; MAGEA11; UBC; ATF4; WTIP; AJUBA; LIMD1; SPRY2; ADRB2; PRPF19; Myog; EGLN3; EGLN2; EGLN1; OS9; HIF3A; WDR83

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 77%; Zebrafish: 75%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.