TOB1 Antibody - middle region : FITC (ARP52105_P050-FITC)

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.

CORO7; APP; DTL; CDC7; PABPC1; CHAF1A; PAN2; UBR5; ELAVL1; SMAD3; CTNNB1; UBC; SKP2; SCMH1; MARCKS; SETDB1; CNOT7; SMAD9; SMAD5; SMAD6; SMAD1; SMAD2; SMAD4; MAPK1; ERBB2; RPS6KA1; MAPK9

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.