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GRK3 Antibody - N-terminal region : FITC (ARP52060_P050-FITC)

Selected Variant

ARP52060_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

G protein-coupled receptor kinase 3

Gene Aliases

BARK2, ADRBK2

Gene ID

157

Swiss Prot

P35626

Accession Number

NP_005151

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ADRBK2

Target

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.

Partner Proteins

UBC; ADRBK1; MYC; GIT1; CCR4; CCR5; OPRM1; CXCR4; BDKRB2; AGTR1

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

ADRBK2 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 100%; Yeast: 80%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

80kDa

References & Citations

Balabanian, K., (2008) J. Clin. Invest. 118 (3), 1074-1084

Shipping Conditions

Wet Ice

Protein Length

688

NCBI Gene Symbol

GRK3

NCBI GB Accession Number

GRK3

Host or Source

Rabbit

Protein Name

Beta-adrenergic receptor kinase 2

Nucleotide Accession Number

NM_005160

Peptide Sequence

FCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC

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