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GRK3 Antibody - N-terminal region : Biotin (ARP52060_P050-Biotin)

Product Specifications

Gene Name

G protein-coupled receptor kinase 3

Gene Aliases

BARK2, ADRBK2

Gene ID

157

Swiss Prot

P35626

Accession Number

NP_005151

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ADRBK2

Target

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.

Partner Proteins

UBC; ADRBK1; MYC; GIT1; CCR4; CCR5; OPRM1; CXCR4; BDKRB2; AGTR1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

ADRBK2 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 100%; Yeast: 80%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

80kDa

References & Citations

Balabanian, K., (2008) J. Clin. Invest. 118 (3), 1074-1084

Shipping Conditions

Wet Ice

Protein Length

688

NCBI Gene Symbol

GRK3

NCBI GB Accession Number

GRK3

Host or Source

Rabbit

Protein Name

Beta-adrenergic receptor kinase 2

Nucleotide Accession Number

NM_005160

Peptide Sequence

FCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC

Frequently Asked Questions

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