CLK2 Antibody - C-terminal region: Biotin (ARP52015_P050-Biotin)

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) ) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants.

TRIM27; ECE1; CLK3; CLK2; YTHDC1; PRPF38A; LNX1; ZNF394; CPSF7; SNIP1; GMCL1; ZNF398; RSRP1; LUZP4; MRPL4; ZNF473; KLHL2; RNPS1; SRRM1; ZNF263; RBM39; ZRSR2; UBE2I; U2AF1; SRPK2; SDCBP; EED; ZNF30; FIP1L1; LUC7L; ZCCHC8; WDR33; CPSF2; PPHLN1; CPSF1; SETD2

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.