CSNK1E Antibody - N-terminal region : Biotin (ARP51987_P050-Biotin)

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. CSNK1E can phosphorylate a large number of proteins. CSNK1E participates in Wnt signaling and is the central component of the circadian clock. It may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. CSNK1E inhibits cytokine-induced granuloytic differentiation.The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.

DVL3; TIAM1; UBC; REST; ZSWIM8; TAZ; SAV1; DVL2; ADAM22; SNX24; AHCYL2; PER1; MCC; HMMR; TCEB2; STK3; SEC13; CSNK1D; CSNK1A1; CRY1; ACACA; FAM83H; FAM83B; VPS13B; FAM199X; KLHDC3; FAM110B; FAM110A; FAM83D; C2orf44; SNX22; STOX2; UNC45A; PPP6R3; WDR5; SDCC

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.