GRK2 Antibody - C-terminal region : Biotin (ARP51966_P050-Biotin)

Product Specifications

Gene Name

G protein-coupled receptor kinase 2

Gene Aliases

BARK1, ADRBK1, BETA-ARK1

Gene ID

156

Swiss Prot

P25098

Accession Number

NP_001610

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human ADRBK1

Target

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.

Partner Proteins

UBC; SUMO1; NEDD8; Rapgef3; GNAQ; FBXO25; ADRBK2; ACACA; HSP90AB1; HSP90AA1; GIT1; RASGRF1; MDM2; EPHA2; PEBP1; ADRB2; SNCA; GRM1; GNB1; KCNIP3; ARRB1; HDAC6; Nedd4; CSNK2B; PDGFRB; TPM2; GIT2; PDE6G; CCR4; AKAP12; PDCL; NCS1; MAPK3; PRKACA; CCR5; PIK3CG

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

ADRBK1 is strongly supported by BioGPS gene expression data to be expressed in PANC1

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.