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CYP11A1 Antibody - middle region : Biotin (ARP51905_P050-Biotin)

Product Specifications

Gene Name

Cytochrome P450, family 11, subfamily A, polypeptide 1

Gene Aliases

CYP11A, CYPXIA1, P450SCC

Gene ID

1583

Swiss Prot

P05108

Accession Number

NP_000772

Host

Rabbit

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CYP11A1

Target

CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP11A1 localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.

Partner Proteins

SMAD9; SMAD3; SMAD2; CYP11B2; FDX1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

CYP11A1 is supported by BioGPS gene expression data to be expressed in HeLa

Concentration

0.5 mg/ml

Homology

Human: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

57kDa

References & Citations

Shigematsu, K., (2008) Eur. J. Endocrinol. 158 (6), 867-878

Shipping Conditions

Wet Ice

Product Datasheet

Anti-CYP11A1 (ARP51905_P050-Biotin) antibody

Protein Length

521

NCBI Gene Symbol

CYP11A1

NCBI GB Accession Number

CYP11A1

Host or Source

Rabbit

Protein Name

Cholesterol side-chain cleavage enzyme, mitochondrial

Nucleotide Accession Number

NM_000781

Peptide Sequence

LRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQW

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