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DCLRE1C Antibody - C-terminal region : HRP (ARP51165_P050-HRP)

Product Specifications

Gene Name

DNA cross-link repair 1C

Gene Aliases

SCIDA, SNM1C, A-SCID, RS-SCID, DCLREC1C

Gene ID

64421

Swiss Prot

Q96SD1

Accession Number

NP_001029029

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human DCLRE1C

Target

DCLRE1C is a nuclear protein that is involved in V (D) J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA) . This gene encodes a nuclear protein that is involved in V (D) J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA) .

Partner Proteins

XRCC5; PRKDC; RAD50; NBN; MRE11A; BRCA1; ATR; ATM; PSMD9; DDB2; DDB1; FBXW7; TP53BP1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

DCLRE1C is supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

65kDa

References & Citations

Bethke, L., (2008) J. Natl. Cancer Inst. 100 (4), 270-276

Shipping Conditions

Wet Ice

Protein Length

572

NCBI Gene Symbol

DCLRE1C

NCBI GB Accession Number

DCLRE1C

Host or Source

Rabbit

Protein Name

Protein artemis

Nucleotide Accession Number

NM_001033857

Peptide Sequence

SQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQER

Frequently Asked Questions

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