PYHIN1 Antibody - N-terminal region : HRP (ARP50876_P050-HRP)
Selected Variant
ARP50876_P050-HRP
Size: 100 µL
Product Specifications
Gene Name
Pyrin and HIN domain family, member 1
Gene Aliases
IFIX
Gene ID
149628
Swiss Prot
Q6K0P9-4
Accession Number
NP_945148
Host
Rabbit
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human PYHIN1
Target
PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Partner Proteins
MDM2
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
51kDa
References & Citations
Ding, Y., (2006) Mol. Cell. Biol. 26 (5), 1979-1996
Shipping Conditions
Wet Ice
Protein Length
452
NCBI Gene Symbol
PYHIN1
NCBI GB Accession Number
PYHIN1
Host or Source
Rabbit
Protein Name
Pyrin and HIN domain-containing protein 1
Nucleotide Accession Number
NM_198930
Peptide Sequence
KMKEEYDKIQIADLMEEKFPGDAGLGKLIEFFKEIPTLGDLAETLKREKL
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