PYHIN1 Antibody - N-terminal region: FITC (ARP50876_P050-FITC)
Product Specifications
Gene Name
Pyrin and HIN domain family, member 1
Gene Aliases
IFIX
Gene ID
149628
Swiss Prot
Q6K0P9-4
Accession Number
NP_945148
Host
Rabbit
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human PYHIN1
Target
PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Partner Proteins
MDM2
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
51kDa
Shipping Conditions
Wet Ice
Protein Length
452
NCBI Gene Symbol
PYHIN1
Protein Name
Pyrin and HIN domain-containing protein 1
Nucleotide Accession Number
NM_198930
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