PYHIN1 Antibody - N-terminal region : FITC (ARP50875_P050-FITC)
Product Specifications
Gene Name
Pyrin and HIN domain family, member 1
Gene Aliases
IFIX
Gene ID
149628
Swiss Prot
Q6K0P9
Accession Number
NP_689714
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human PYHIN1
Target
PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Partner Proteins
MDM2
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 91%; Dog: 91%; Horse: 91%; Human: 100%; Mouse: 100%; Pig: 85%; Rabbit: 93%; Rat: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
55kDa
References & Citations
Ding, Y., (2006) Mol. Cell. Biol. 26 (5), 1979-1996
Shipping Conditions
Wet Ice
Protein Length
492
NCBI Gene Symbol
PYHIN1
NCBI GB Accession Number
PYHIN1
Host or Source
Rabbit
Protein Name
Pyrin and HIN domain-containing protein 1
Nucleotide Accession Number
NM_152501
Peptide Sequence
ANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADL
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