C19orf2 Antibody - middle region : Biotin (ARP50771_P050-Biotin)

Product Specifications

Gene Name

URI1, prefoldin-like chaperone

Gene Aliases

RMP, URI, NNX3, C19orf2, PPP1R19

Gene ID

8725

Swiss Prot

Q6NX55

Accession Number

NP_604431

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human C19orf2

Target

The function of the C19orf2 protein remains unknown.The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Partner Proteins

RPAP3; UBC; ITCH; NEDD4; ATF7; TTI1; RUVBL1; RPS6KB1; PPP1CC; HSP90AA1; APP; UXT; RPAP2; GPN1; RUVBL2; STAP1; POLR2E; URI1; DMAP1; GTF2F2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that URI1 is expressed in Hela, HepG2, MCF7

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 100%; Rat: 80%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.