SIN3B Antibody - middle region : Biotin (ARP50590_P050-Biotin)

Product Specifications

Gene Name

SIN3 transcription regulator homolog B (yeast)

Gene Aliases

KIAA0700

Gene ID

23309

Swiss Prot

O75182

Accession Number

NP_056075

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SIN3B

Target

SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also, it interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. The gene is also able to form a complex with FOXK1 which represses transcription

Partner Proteins

SOX2; HDAC1; HDAC2; UBC; ESR1; AR; TFAP4; TP53; SUMO2; KLF16; MORF4L1; MORF4L2; MRGBP; KDM5A; CIITA; NR1D2; COPS2; SMN1; PBX1; REST; ZBTB4; ARID4A; MYT1; MXI1; SAP25; SMARCE1; SMARCB1; SMARCA4; SMARCA2; CBFA2T3; RNF220; ZBTB16; SETDB1; HDAC9; IKZF4; IKZF1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rat: 79%; Zebrafish: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.