SIN3B Antibody - middle region : HRP (ARP50589_P050-HRP)
Product Specifications
Gene Name
SIN3 transcription regulator homolog B (yeast)
Gene Aliases
KIAA0700
Gene ID
23309
Swiss Prot
O75182
Accession Number
NP_056075
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SIN3B
Target
SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities.It also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. SIN3B also forms a complex with FOXK1 which represses transcription.
Partner Proteins
SOX2; HDAC1; HDAC2; UBC; ESR1; AR; TFAP4; TP53; SUMO2; KLF16; MORF4L1; MORF4L2; MRGBP; KDM5A; CIITA; NR1D2; COPS2; SMN1; PBX1; REST; ZBTB4; ARID4A; MYT1; MXI1; SAP25; SMARCE1; SMARCB1; SMARCA4; SMARCA2; CBFA2T3; RNF220; ZBTB16; SETDB1; HDAC9; IKZF4; IKZF1
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 93%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
133kDa
References & Citations
Dhanda, R.S., (er) BMC Mol. Biol. 9, 8 (2008)
Shipping Conditions
Wet Ice
Protein Length
1162
NCBI Gene Symbol
SIN3B
NCBI GB Accession Number
SIN3B
Host or Source
Rabbit
Protein Name
Paired amphipathic helix protein Sin3b
Nucleotide Accession Number
NM_015260
Peptide Sequence
NDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILE
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