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CASP8AP2 Antibody - N-terminal region : HRP (ARP50555_P050-HRP)

Selected Variant

ARP50555_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Caspase 8 associated protein 2

Gene Aliases

CED-4, FLASH, RIP25

Gene ID

9994

Swiss Prot

Q9UKL3

Accession Number

NP_036247

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human CASP8AP2

Target

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.

Partner Proteins

Ced-3; BCL2L1; PML; CTBP2; CREM; SUMO1; SUMO2; PIAS1; CASP10; TRIM21; UBC; CALM1; UBE2I; SREBF2; GLUL; SP100; CASP8AP2; FADD; TRAF2; CASP8; FAS

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 86%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

223kDa

References & Citations

Jeong, E.G., (2008) Pathology 40 (1), 31-34

Shipping Conditions

Wet Ice

Protein Length

1982

NCBI Gene Symbol

CASP8AP2

NCBI GB Accession Number

CASP8AP2

Host or Source

Rabbit

Protein Name

CASP8-associated protein 2

Nucleotide Accession Number

NM_012115

Peptide Sequence

SLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTV

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