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TUSC4 Antibody - N-terminal region : Biotin (ARP50539_P050-Biotin)

Product Specifications

Gene Name

Nitrogen permease regulator-like 2 (S. cerevisiae)

Gene Aliases

NPR2, NPR2L, TUSC4, FFEVF2

Gene ID

10641

Swiss Prot

Q8WTW4

Accession Number

NP_006536

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human TUSC4

Target

TUSC4 suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. TUSC4 down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. TUSC4 may act as a tumor suppressor. TUSC4 suppresses cell growth and enhanced sensitivity to various anticancer drugs.

Partner Proteins

UBC; HSP90AA1; CDKN1A; ANXA7; NPRL3; UBE2M; PRKAR1A

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

NPRL2 is supported by BioGPS gene expression data to be expressed in OVCAR3

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

44kDa

References & Citations

Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007)

Shipping Conditions

Wet Ice

Protein Length

380

NCBI Gene Symbol

NPRL2

NCBI GB Accession Number

NPRL2

Host or Source

Rabbit

Protein Name

Nitrogen permease regulator 2-like protein

Nucleotide Accession Number

NM_006545

Peptide Sequence

MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPEL

Frequently Asked Questions

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