NUMA1 Antibody - C-terminal region : Biotin (ARP50532_P050-Biotin)
Product Specifications
Gene Name
Nuclear mitotic apparatus protein 1
Gene Aliases
NUMA, NMP-22
Gene ID
4926
Swiss Prot
Q14980
Accession Number
NP_006176
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human NUMA1
Target
NuMA is a structural element in maintaining nuclear integrity. A critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, spatially restricts APC/C activity in early mitosis. The entire coding region and exon-intron boundaries of NuMa were screened in 92 familial breast cancer patients. But the results do not support the role of NuMA variants as breast cancer susceptibility alleles.
Partner Proteins
CCDC57; GMCL1; BRAP; DVL3; DVL2; DVL1; UBC; LGR4; ERG; RPA3; RPA2; RPA1; RNF2; EZH2; BMI1; SUZ12; EED; YWHAQ; LMNA; CBX6; WHSC1; HSP90AB1; HSP90AA1; ESR1; CDK6; VCP; SMURF1; MDC1; TP53BP1; ECT2; NCSTN; DDB1; EMILIN1; DYNLL1; RAE1; NUP98; CDK2; TERF2IP; TE
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
238kDa
References & Citations
Kilpivaara, O., (er) BMC Cancer 8, 71 (2008)
Shipping Conditions
Wet Ice
Protein Length
2115
NCBI Gene Symbol
NUMA1
NCBI GB Accession Number
NUMA1
Host or Source
Rabbit
Protein Name
Nuclear mitotic apparatus protein 1
Nucleotide Accession Number
NM_006185
Peptide Sequence
AQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL
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