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ING1 Antibody - C-terminal region : HRP (ARP50512_T100-HRP)

Selected Variant

ARP50512_T100-HRP

Size: 100 µL

Product Specifications

Gene Name

Inhibitor of growth family, member 1

Gene Aliases

P33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a

Gene ID

3621

Swiss Prot

Q5T9H0

Accession Number

NP_937862

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human ING1

Target

ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of ING1 gene have been detected in various cancers.This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Partner Proteins

SIRT1; SIRT2; UBC; HDAC1; KIAA0101; PCNA; RBP1; RBBP7; RBBP4; HDAC2; BRMS1L; SIN3A; BRMS1; SAP30; ELAVL1; SMURF1; COPS2; NQO1; HIST2H3C; MRGBP; YWHAZ; YWHAH; YWHAG; YWHAE; YWHAB; KPNA2; KPNB1; YWHAQ; SFN; ESR1; LMNA; CDKN2A; TP53; KAT2B; DMAP1; EP300; HHT

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Sample Type

There is BioGPS gene expression data showing that ING1 is expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

32kDa

References & Citations

Ahmed, I.A., (2008) Colorectal Dis 10 (4), 344-351

Shipping Conditions

Wet Ice

Protein Length

279

NCBI Gene Symbol

ING1

NCBI GB Accession Number

ING1

Host or Source

Rabbit

Protein Name

Inhibitor of growth protein 1

Nucleotide Accession Number

NM_198219

Peptide Sequence

EKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCD

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