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HSD3B7 Antibody - middle region : Biotin (ARP49934_P050-Biotin)

Selected Variant

ARP49934_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

Gene Aliases

CBAS1, PFIC4, SDR11E3

Gene ID

80270

Swiss Prot

Q9H2F3

Accession Number

NP_079469

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human HSD3B7

Target

This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Partner Proteins

NOTCH2NL; KRTAP10-3; KRTAP10-8; KRTAP10-1; KRTAP10-9; KRTAP4-2; SPRY2; UBC; KRTAP10-7; DAPP1; PYGL; ICAM1; Hoxa1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

41kDa

Shipping Conditions

Wet Ice

Protein Length

369

NCBI Gene Symbol

HSD3B7

NCBI GB Accession Number

HSD3B7

Host or Source

Rabbit

Protein Name

3 beta-hydroxysteroid dehydrogenase type 7

Nucleotide Accession Number

NM_025193

Peptide Sequence

QGTRNVIEACVQTGTRFLVYTSSMEVVGPNTKGHPFYRGNEDTPYEAVHR

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