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SIGIRR Antibody - C-terminal region : FITC (ARP49664_P050-FITC)

Selected Variant

ARP49664_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Gene Aliases

TIR8, IL-1R8

Gene ID

59307

Swiss Prot

Q6IA17

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR

Target

SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.

Partner Proteins

APP; UBC; SIGIRR; TLR9; TLR5; TLR4; TRAF6; IRAK1; RPN1; IL1R1; ENO2

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

25kDa

Shipping Conditions

Wet Ice

Protein Length

224

NCBI Gene Symbol

SIGIRR

NCBI GB Accession Number

SIGIRR

Host or Source

Rabbit

Peptide Sequence

PVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM

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