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SMPD3 Antibody - middle region : FITC (ARP49331_P050-FITC)

Selected Variant

ARP49331_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)

Gene Aliases

NSMASE2

Gene ID

55512

Swiss Prot

Q9NY59

Accession Number

NP_061137

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SMPD3

Target

SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. SMPD3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

71kDa

References & Citations

Tani, M. (2007) FEBS Lett. 581 (7), 1323-1328

Shipping Conditions

Wet Ice

Protein Length

655

NCBI Gene Symbol

SMPD3

NCBI GB Accession Number

SMPD3

Host or Source

Rabbit

Protein Name

Sphingomyelin phosphodiesterase 3

Nucleotide Accession Number

NM_018667

Peptide Sequence

RPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLV

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