MAP4K4 Antibody - N-terminal region : Biotin (ARP49031_P050-Biotin)

Product Specifications

Gene Name

Mitogen-activated protein kinase kinase kinase kinase 4

Gene Aliases

HGK, NIK, MEKKK4, FLH21957, HEL-S-31

Gene ID

9448

Swiss Prot

O95819

Accession Number

NP_004825

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human MAP4K4

Target

MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act upstream of the JUN N-terminal pathway.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Partner Proteins

UBC; MOB1B; NME7; PPP1CC; HSP90AA1; PAXIP1; GRK5; TRAPPC9; PPP1CA; KIF26B; HIST2H2BE; SLC9A1; PRKCE; KIF5A; ZRANB1; DOK1; MAP3K7; NCK1; GBP3; RAP2A; RASA1; ITGB1; MAP3K1; BRCA1; ATL1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.