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PELI2 Antibody - N-terminal region : Biotin (ARP48876_P050-Biotin)

Selected Variant

ARP48876_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Pellino E3 ubiquitin protein ligase family member 2

Gene ID

57161

Swiss Prot

Q9HAT8

Accession Number

NP_067078.1

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Human PELI2

Target

PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Partner Proteins

SRPK1; FRYL; CREB3L3; THAP7; ERO1L; DEAF1; LAMC3; PICALM; LTBP3; IRAK1; HNRNPK; FN1; UBC; UBQLN4; IRAK4; TRAF6; NR2C2; BCL10; MYD88; IRAK2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

46 kDa

Shipping Conditions

Wet Ice

Protein Length

420

NCBI Gene Symbol

PELI2

NCBI GB Accession Number

PELI2

Host or Source

Rabbit

Protein Name

E3 ubiquitin-protein ligase pellino homolog 2

Peptide Sequence

STISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMD

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