NSUN2 Antibody - N-terminal region : Biotin (ARP48810_P050-Biotin)
Selected Variant
ARP48810_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
NOP2/Sun RNA methyltransferase family, member 2
Gene Aliases
MISU, MRT5, SAKI, TRM4
Gene ID
54888
Swiss Prot
Q08J23
Accession Number
NP_060225
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human NSUN2
Target
NSUN2 is a RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. NSUN2 methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA (Leu) (CAA) precursors, and at positions 48, 49 and 50 of tRNA (Gly) (GCC) precursors. It may act downstream of Myc to regulate epidermal cell growth and proliferation. And it is required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
Partner Proteins
SUMO2; SUMO3; UBC; SUMO1; NEDD8; TP53RK; PUS1; EFTUD1; XPO5; UGGT1; OSGEP; PANK4; THG1L; SH3GLB1; KIAA1279; UBXN7; TTLL12; ARPC2; ACTR2; ACTR3; FUBP1; TSN; SH3GL1; RPA1; RDX; RANGAP1; PPP2CB; PFDN5; PFDN1; NRD1; PPP1R12A; HARS; GTF2E1; CALU; CALR; UBD; VC
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
84kDa
Shipping Conditions
Wet Ice
Protein Length
767
NCBI Gene Symbol
NSUN2
NCBI GB Accession Number
NSUN2
Host or Source
Rabbit
Protein Name
TRNA (cytosine (34) -C (5) ) -methyltransferase
Peptide Sequence
LEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKT
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