GSAP Antibody - N-terminal region : Biotin (ARP48798_P050-Biotin)
Selected Variant
ARP48798_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
Pigeon homolog (Drosophila)
Gene Aliases
PION
Gene ID
54103
Swiss Prot
A4D1B5
Accession Number
NP_059135
Host
Rabbit
Reactivity
Human, Rat, Cow, Dog, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human GSAP
Target
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease. Formation of amyloid-beta is catalyzed by gamma-secretase, a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein C-terminal fragment (APP-CTF) .
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity purified
Concentration
0.5 mg/ml
Homology
Cow: 85%; Dog: 85%; Horse: 93%; Human: 100%; Rabbit: 93%; Rat: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
93kDa
Shipping Conditions
Wet Ice
Protein Length
854
NCBI Gene Symbol
GSAP
NCBI GB Accession Number
GSAP
Host or Source
Rabbit
Protein Name
Gamma-secretase-activating protein
Peptide Sequence
QTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSK
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