POLK Antibody - N-terminal region : FITC (ARP48792_P050-FITC)
Product Specifications
Gene Name
Polymerase (DNA directed) kappa
Gene Aliases
DINP, POLQ, DINB1
Gene ID
51426
Swiss Prot
Q9UBT6
Accession Number
NP_057302
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human POLK
Target
POLK belongs to the DNA polymerase type-Y family. It contains 2 Rad18-type zinc fingers and 1 umuC domain. POLK is a DNA polymerase specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. It lacks 3'-5' proofreading exonuclease activity. POLK forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Partner Proteins
XPO7; MSH2; MCM6; MCM4; MSH6; TRAIP; UBC; REV1; Shprh; RAD18; PCNA; XRCC1; RPA1; POLD1
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 86%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
99kDa
References & Citations
Hile, S.E. (2008) Nucleic Acids Res. 36 (2), 688-696
Shipping Conditions
Wet Ice
Protein Length
870
NCBI Gene Symbol
POLK
NCBI GB Accession Number
POLK
Host or Source
Rabbit
Protein Name
DNA polymerase kappa
Nucleotide Accession Number
NM_016218
Peptide Sequence
KINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQL
Frequently Asked Questions
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