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PYGB Antibody - N-terminal region : Biotin (ARP48587_P050-Biotin)

Product Specifications

Gene Name

Phosphorylase, glycogen; brain

Gene Aliases

GPBB

Gene ID

5834

Swiss Prot

P11216

Accession Number

NP_002853

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PYGB

Target

PYGB is a glycogen phosphorylase found predominantly in the brain. It forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

UBC; SIAH1; PYGL; PYGB; SUMO2; SUMO3; WDR61; RIC8A; OGFOD1; UBA6; UBR7; LIMD1; XPNPEP1; PLCG1; FH; NPM1; CPNE1; PSMB2; CAND1; SIRT7; MLH1; ACTN1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 92%; Guinea Pig: 86%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 92%; Sheep: 85%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

97kDa

References & Citations

Lee, M.K., (2006) Pathology 38 (6), 555-560

Shipping Conditions

Wet Ice

Protein Length

843

NCBI Gene Symbol

PYGB

NCBI GB Accession Number

PYGB

Host or Source

Rabbit

Protein Name

Glycogen phosphorylase, brain form

Nucleotide Accession Number

NM_002862

Peptide Sequence

ADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDT

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