BAG3 Antibody - middle region : Biotin (ARP48251_P050-Biotin)

Product Specifications

Gene Name

BCL2-associated athanogene 3

Gene Aliases

BIS, MFM6, BAG-3, CAIR-1

Gene ID

9531

Swiss Prot

O95817

Accession Number

NP_004272

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human BAG3

Target

BAG3 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

SF3B4; DAZAP2; ARRDC3; LITAF; MAGED1; PDE9A; HSPA8; PHLDB1; HSPB1; HSF1; STUB1; DNAJB6; AMOT; PDLIM7; MLF2; HSPB8; WBP2; UBC; MCM7; HSP90AB1; ETFA; MVP; ACLY; PSAP; PSME1; PSMD12; PSMD9; PSMD8; PSMD5; PSMD3; PSMD2; PSMC5; PSMC3; PSMC2; PSMC1; PSMB5; PSMB4

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

BAG3 is supported by BioGPS gene expression data to be expressed in HT1080

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.