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PSMD8 Antibody - C-terminal region : HRP (ARP48216_P050-HRP)

Selected Variant

ARP48216_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8

Gene Aliases

S14, p31, HIP6, HYPF, Nin1p, Rpn12, HEL-S-91n

Gene ID

5714

Swiss Prot

P48556

Accession Number

AAV38494

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PSMD8

Target

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. PSMD8 is a non-ATPase subunit of the 19S regulator. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

Partner Proteins

HUWE1; UBC; PSMD14; TXNL1; PPFIA1; RPS21; RPS12; RPS8; PSMD11; PSMD7; PSMD4; PSMD3; PSMD2; PSMD1; PSMC6; PSMC5; PSMC4; PSMC2; PSMC1; MAP2; DYNC1I2; DHX9; ABCF1; KCMF1; UCHL5; DYNC1LI1; KIAA0368; ADRM1; HNRNPA0; PARK2; RNF11; BAG3; NOS2; SMAD9; SMAD2; PSMD

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

27kDa

Shipping Conditions

Wet Ice

Protein Length

257

NCBI Gene Symbol

PSMD8

NCBI GB Accession Number

PSMD8

Host or Source

Rabbit

Protein Name

26S proteasome non-ATPase regulatory subunit 8

Nucleotide Accession Number

P48556

Peptide Sequence

DYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV

Subunit

8

Price

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