PSMD8 Antibody - C-terminal region : Biotin (ARP48216_P050-Biotin)

Product Specifications

Gene Name

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8

Gene Aliases

S14, p31, HIP6, HYPF, Nin1p, Rpn12, HEL-S-91n

Gene ID

5714

Swiss Prot

P48556

Accession Number

AAV38494

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PSMD8

Target

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. PSMD8 is a non-ATPase subunit of the 19S regulator. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

Partner Proteins

HUWE1; UBC; PSMD14; TXNL1; PPFIA1; RPS21; RPS12; RPS8; PSMD11; PSMD7; PSMD4; PSMD3; PSMD2; PSMD1; PSMC6; PSMC5; PSMC4; PSMC2; PSMC1; MAP2; DYNC1I2; DHX9; ABCF1; KCMF1; UCHL5; DYNC1LI1; KIAA0368; ADRM1; HNRNPA0; PARK2; RNF11; BAG3; NOS2; SMAD9; SMAD2; PSMD

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.