CRYAB Antibody - C-terminal region : Biotin (ARP48196_T100-Biotin)

Alpha crystallins are composed of: alpha-A and alpha-B, for acidic and basic, respectively. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

CRYAB; CRYAA; KRTAP19-5; KRTAP8-1; TRAPPC6A; MRPL11; TNPO2; ACOT7; HSPB1; CASP7; CASP3; CASP2; PIDD1; DDX20; CRADD; B2M; APOC2; XIAP; CASP12; SOD1; HSPB2; HBA1; CASP9; CASP8; CASP6; ASB5; SMAD4; TRIM33; UBC; CCL22; CTNNB1; CRYGD; CDH1; SNCA; GFAP; FGF2; F

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.