EIF3E Antibody - middle region : HRP (ARP48176_P050-HRP)

Product Specifications

Gene Name

Eukaryotic translation initiation factor 3, subunit E

Gene Aliases

INT6, EIF3S6, EIF3-P48, eIF3-p46

Gene ID

3646

Swiss Prot

P60228

Accession Number

NP_001559

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human EIF3E

Target

EIF3E belongs to the eIF-3 subunit E family.It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. EIF3E is required for nonsense-mediated mRNA decay (NMD) ; It may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. The protein may interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Partner Proteins

UBC; C4orf19; RUNDC3A; HUWE1; TRIM63; TRIM55; STAU1; SUMO1; NEDD8; GPRASP2; LARP1; GNB2L1; RPS28; RPS25; RPS23; RPS20; RPS19; RPS18; RPS12; RPS10; RPS9; RPS8; RPS3A; RPS3; RPS2; EIF3CL; DYNC1LI1; FBXO6; EIF3D; IGSF8; NPM1; ICAM1; CD81; EIF3B; VCAM1; POLR2

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.