PDHA1 Antibody - N-terminal region : FITC (ARP48136_T100-FITC)

The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1) ; dihydrolipoyl transacetylase (DLAT) ; and dihydrolipoyl dehydrogenase (DLD) . The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex.The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1) ; dihydrolipoyl transacetylase (DLAT; MIM 608770) (E2; EC 2.3.1.12) ; and dihydrolipoyl dehydrogenase (DLD; MIM 238331) (E3; EC 1.8.1.4) . The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]) .[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

HUWE1; SUMO2; UBC; GINS4; DCPS; NCDN; VCL; PPP1R2; MSN; ASL; ADRB2; ITGA4; HNRNPDL; PDHX; SDHA; PDHB; OGDH; GTF2I; DLAT; CUL3; SIRT7; ATG101; WDR20; BABAM1; USP19; PDP1; EIF6; PDK4; PDK3; PDK2; PDK1; PDHA1; DGKE

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.