AKT1S1 Antibody - C-terminal region : Biotin (ARP48061_P050-Biotin)
Product Specifications
Gene Name
AKT1 substrate 1 (proline-rich)
Gene Aliases
Lobe, PRAS40
Gene ID
84335
Swiss Prot
Q96B36
Accession Number
NP_115751
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human AKT1S1
Target
AKT1S1 may play an important role in phosphatidylinositol 3-kinase (PI3K) -AKT1 survival signaling. It is the substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. AKT1S1 may also play a role in nerve growth factor-mediated neuroprotection.AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]) .[supplied by OMIM].
Partner Proteins
MTOR; RPTOR; SGK1; RICTOR; MAPKAP1; MLST8; FAM114A1; YWHAQ; YWHAB; SQSTM1; RPS6KA5; TCEA2; YWHAG; EIF6; AKT2; AKT1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB, IHC
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
27kDa
References & Citations
Fonseca, B.D., (2008) Biochem. J. 411 (1), 141-149
Shipping Conditions
Wet Ice
Protein Length
256
NCBI Gene Symbol
AKT1S1
NCBI GB Accession Number
AKT1S1
Host or Source
Rabbit
Protein Name
Proline-rich AKT1 substrate 1
Nucleotide Accession Number
NM_032375
Peptide Sequence
KSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAE
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