NDE1 Antibody - middle region : Biotin (ARP47932_P050-Biotin)

Product Specifications

Gene Name

NudE nuclear distribution E homolog 1 (A. nidulans)

Gene Aliases

NDE, LIS4, MHAC, NUDE, NUDE1, HOM-TES-87

Gene ID

54820

Swiss Prot

Q9NXR1-2

Accession Number

NP_060138

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human NDE1

Target

NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex

Partner Proteins

FAM9B; LZTS2; USHBP1; NDEL1; ZNF398; NDE1; WAC; UBQLN1; MED4; DISC1; TFIP11; CEP250; NDC80; ARNT2; BZRAP1; MKRN3; TTC1; TRIM27; REL; HOXA2; GOLGA2; AR; YWHAQ; PAFAH1B1; ZNF365; YWHAG; TUBG1; MAPK1; CDK1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

NDE1 is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.