PLEKHO1 Antibody - N-terminal region : HRP (ARP47817_P050-HRP)

PLEKHO1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP) .PLEKHO1 may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2) . PLEKHO1 appears to target ATM to the plasma membrane. PLEKHO1 appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. PLEKHO1 is also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

PLEKHO1; AKT3; AKT2; AKT1; UBC; GSK3B; TRAF6; Arpc1a; Stub1; Rps3a1; SMURF1; PSMC5; USP7; C10orf88; RPS20; IFI35; DNAJB1; FLNB; CSNK2A1; SMAD5; JUND; JUN; CASP3

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.