What sizes are available for FBXW7 Antibody - C-terminal region : HRP (ARP47419_P050-HRP)?

FBXW7 Antibody - C-terminal region : HRP (ARP47419_P050-HRP) is available in the following size(s): 100 µL.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

FBXW7 Antibody - C-terminal region : HRP (ARP47419_P050-HRP)

Q: What is the catalog number for FBXW7 Antibody - C-terminal region : HRP (ARP47419_P050-HRP)?

The catalog number for FBXW7 Antibody - C-terminal region : HRP (ARP47419_P050-HRP) is ARP47419_P050-HRP.

Selected Variant

ARP47419_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

Gene Aliases

AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10

Gene ID

55294

Swiss Prot

Q969H0-4

Accession Number

NP_001013433

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7

Target

FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.

Partner Proteins

MCL1; CDC34; CCNE1; FBXW7; CUL1; UBE2D1; PIN1; DAB2IP; YAP1; SKP1; MAP4K1; EYA1; KLF5; SREBF1; NOTCH1; UBE2QL1; Creb3l2; Creb3l1; SIC1; CSF3R; KLF2; NCOA3; PTEN; NFE2L1; HSP90AA1; MED11; MED19; MED8; MED30; MED10; MED28; MED29; MED9; MED15; MED31; MED4; M

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

FBXW7 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

80kDa

Shipping Conditions

Wet Ice

Protein Length

707

NCBI Gene Symbol

FBXW7

NCBI GB Accession Number

FBXW7

Host or Source

Rabbit

Protein Name

F-box/WD repeat-containing protein 7

Nucleotide Accession Number

NM_001013415

Peptide Sequence

LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVL

Price

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