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CLN6 Antibody - middle region : HRP (ARP47371_P050-HRP)

Product Specifications

Gene Name

Ceroid-lipofuscinosis, neuronal 6, late infantile, variant

Gene Aliases

Nclf, CLN4A, HsT18960

Gene ID

54982

Swiss Prot

Q9NWW5

Accession Number

NP_060352

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CLN6

Target

CLN6 is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL) . Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely CLN6 involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.

Partner Proteins

RNF2; BMI1; ILK; env; DERL1; VCP; UBC

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 93%; Zebrafish: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

36kDa

References & Citations

Heine, C., (2007) Mol. Membr. Biol. 24 (1), 74-87

Shipping Conditions

Wet Ice

Product Datasheet

Anti-CLN6 (ARP47371_P050-HRP) antibody

Protein Length

311

NCBI Gene Symbol

CLN6

NCBI GB Accession Number

CLN6

Host or Source

Rabbit

Protein Name

Ceroid-lipofuscinosis neuronal protein 6

Nucleotide Accession Number

NM_017882

Peptide Sequence

LPRSITYVSIIIFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNL

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